Nicotinamide adenine dinucleotide (NAD+) is a coenzyme present in every cell that plays a critical role in energy metabolism, DNA repair, and cellular signaling. NAD+ levels decline significantly with age. Physician-supervised subcutaneous injection protocols.
NAD+ is involved in over 500 enzymatic reactions including: converting nutrients into cellular energy (ATP), activating sirtuins (proteins linked to longevity and cellular repair), repairing damaged DNA, and regulating circadian rhythm. Research in animal models has shown that boosting NAD+ levels can improve metabolic function, cognitive performance, and markers associated with aging.
Honest framing: While the basic science is compelling, large-scale human clinical trials specifically for NAD+ supplementation and longevity outcomes are still underway. Current evidence is primarily preclinical plus small human trials. Your physician will discuss what is and isn't known.
Common: flushing, nausea, warm sensation, discomfort at injection site, headache. Typically mild and transient; many patients experience an initial flushing sensation that diminishes with continued use. Requires refrigeration; shorter beyond-use date than most medications (typically 30–60 days once reconstituted).
Medical disclaimer: Not FDA-approved for anti-aging; off-label use. Educational content. Page medically reviewed by Teja V. Surapaneni, MD, MS (NV, WA, OR, WY). Last reviewed: April 17, 2026